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A synchondrosis (or primary cartilaginous joint) is a type of cartilaginous joint where hyaline cartilage completely joins together two bones. [1] Synchondroses are different from symphyses (secondary cartilaginous joints), which are formed of fibrocartilage , and from synostosis (ossified junctions), which is the fusion of two or more bones.
Radiation therapy, which kills cancer cells with focused doses of radiation, is often indicated in the treatment of rhabdomyosarcoma, and the exclusion of this treatment from disease management has been shown to increase recurrence rates. Radiation therapy is used when resecting the entirety of the tumor would involve disfigurement or loss of ...
This is best accomplished by evaluation of the patient's blood, bone marrow, and occasionally lymph node cells by a pathologist with specific training in blood disorders. A flow cytometer is necessary for cell marker analysis, and the detection of genetic problems in the cells may require visualizing the DNA changes with fluorescent probes by FISH.
Severe combined immunodeficiency (SCID), also known as Swiss-type agammaglobulinemia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in differing clinical presentations. [2]
A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor cells, often called blasts. Examples are nephroblastoma, medulloblastoma, and retinoblastoma. The suffix -blastoma is used to imply a tumor of primitive, incompletely differentiated (or precursor) cells, e.g., chondroblastoma is composed of ...
They account for less than 1% of all new cancer cases each year. [21] In 2023, about 14,300 new cases were diagnosed in the United States. [21] Soft-tissue sarcomas are more commonly found in older patients (>50 years old), although in children and adolescents under age 20, certain histologies are common (rhabdomyosarcoma, synovial sarcoma). [13]
Prophylactic surgery in children has largely been justified through two grounds, the best interest of the child and public health. Since children are unlikely to be able to provide a meaningfully informed consent , it is an ethical subject discussed and heavily contested by various bioethics committees and the public.
Children whose cranial plates fuse too early may suffer deformities and brain damage as the skull does not expand properly to accommodate the growing brain, a condition known as craniosynostosis. Synchondrosis is a cartilaginous joint connected by hyaline cartilage , as seen in the epiphyseal plate .