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A non-ossifying fibroma (NOF) is a benign bone tumor of the osteoclastic, giant cell-rich tumor type. [1] It generally occurs in the metaphysis of long bones in children and adolescents. [ 2 ] Typically, there are no symptoms unless there is a fracture . [ 2 ]
The most common bone tumor is a non-ossifying fibroma. [4] Average five-year survival in the United States after being diagnosed with bone and joint cancer is 67%. [5] The earliest known bone tumor was an osteosarcoma in a foot bone discovered in South Africa, between 1.6 and 1.8 million years ago. [6]
Bone pain is a common complication of fibrous dysplasia. It may present at any age, but most commonly develops during adolescence and progresses into adulthood. [7] Bone marrow stromal cells in fibrous dysplasia produce excess amounts of the phosphate-regulating hormone fibroblast growth factor-23 (FGF23), leading to loss of phosphate in the ...
Osteofibrous dysplasia is a rare, benign non-neoplastic condition with no known cause. It is considered a fibrovascular defect. Campanacci described this condition in two leg bones, the tibia and fibula, [1] and coined the term. This condition should be differentiated from nonossifying fibroma and fibrous dysplasia of bone.
The term fibromatosis refers to a group of soft tissue tumors [1] which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence.
A dermatofibroma, or benign fibrous histiocytomas, is a benign nodule in the skin, typically on the legs, elbows or chest of an adult. [3] It is usually painless. [3]It usually ranges from 0.2cm to 2cm in size but larger examples have been reported. [3]
In medicine, a desmoplastic fibroma is a low-grade malignant, locally aggressive, fibrous and rare tumor of the bone, affecting children and young adults, potentially resulting in cortical bone destruction. It usually affects craniofacial bones, mandible most frequently, long bones (metaphyseal femur, tibia, humerus). [1]
Patients typically present with swelling with or without pain. The slow-growing tumor predominantly arises in long bones in a subcortical location (95% in the tibia or fibula). [3] Benign osteofibrous dysplasia may be a precursor of adamantinoma [4] [7] or a regressive phase of adamantinoma. [8]