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The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. [2] In eukaryotes , it extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms.
Intermediate filaments (IFs) are cytoskeletal structural components found in the cells of vertebrates, and many invertebrates. [1] [2] [3] Homologues of the IF protein have been noted in an invertebrate, the cephalochordate Branchiostoma.
It anchors organelles within the cells and makes up the structure and stability of the cell. The cytoskeleton is composed of three principal types of protein filaments: actin filaments, intermediate filaments, and microtubules, which are held together and linked to subcellular organelles and the plasma membrane by a variety of accessory proteins.
Zonula Occludin 1 (ZO-1) serves as the scaffolding protein for the tight junction. This means that it directly links the tight junction proteins to the f-actin cytoskeleton. In addition to anchoring claudins, occludin, and JAMs to the apical region of the cell membrane, ZO-1 has also been implicated in important cellular processes such as ...
Inside a cilium and a flagellum is a microtubule-based cytoskeleton called the axoneme. The axoneme of a primary cilium typically has a ring of nine outer microtubule doublets (called a 9+0 axoneme), and the axoneme of a motile cilium has two central microtubules in addition to the nine outer doublets (called a 9+2 axoneme).
A 3D diagram of a centriole. Each circle represents one microtubule. In total there are 27 microtubules organized into 9 bundles of 3. The centrosome is the main MTOC (microtubule organizing center) of the cell during mitosis. Each centrosome is made up of two cylinders called centrioles, oriented at right angles to each other. The centriole is ...
Together with an alpha-beta catenin complex, the cadherin can bind to the microfilaments of the cytoskeleton of the cell. This allows for homophilic cell–cell adhesion. [18] The β-catenin–α-catenin linked complex at the adherens junctions allows for the formation of a dynamic link to the actin cytoskeleton. [19]
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils.It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm.