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Hyperalgesia (/ ˌ h aɪ p ər æ l ˈ dʒ iː z i ə / or /-s i ə /; hyper from Greek ὑπέρ (huper) 'over' + -algesia from Greek ἄλγος (algos) 'pain') is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus.
Hypoalgesia or hypalgesia denotes a decreased sensitivity to painful stimuli. Hypoalgesia occurs when nociceptive (painful) stimuli are interrupted or decreased somewhere along the path between the input (nociceptors), and the places where they are processed and recognized as pain in the conscious mind. Hypoalgesic effects can be mild, such as ...
Other notable sex difference findings from his group include a meta-analysis showing that women are more sensitive to pain than men; [19] morphine analgesia, stress-induced analgesia, and opioid-induced hyperalgesia are mediated by different neurochemical receptors in the two sexes (NMDA receptors and V1AR receptors in males, and MC1Rs in ...
Congenital insensitivity to pain (CIP), also known as congenital analgesia, is one or more extraordinarily rare conditions in which a person cannot feel (and has never felt) physical pain. [1] The conditions described here are separate from the HSAN group of disorders, which have more specific signs and cause.
Pain tolerance is the maximum level of pain that a person is able to tolerate. Pain tolerance is distinct from pain threshold (the point at which pain begins to be felt). [1] The perception of pain that goes in to pain tolerance has two major components. First is the biological component—the headache or skin prickling that activates pain ...
The subjects with CU traits had higher pain thresholds than the controls, which suggests they were less sensitive to noxious pain. The results show the CU-trait juvenile's lack of pain empathy was due to a lack of arousal due to another person's distress rather than a lack of understanding of the other's emotional state. [22]
Aδ fibers are characterized by thin axons and thin myelin sheaths, and are either D-hair receptors or nociceptive neurons. Aδ fibers conduct at a rate of up to 25 m/s. D-hair receptors have large receptive fields and very low mechanical thresholds, and have been shown to be the most sensitive of known cutaneous mechanoreceptors.
As long as humans have experienced pain, they have given explanations for its existence and sought soothing agents to dull or cease painful sensations.Archaeologists have uncovered clay tablets dating back as far as 5,000 BC which reference the cultivation and use of the opium poppy to bring joy and cease pain.