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Drug-induced liver injury, as Hy's law states, patients with bilirubin of >3 mg/dL have 10% mortality rate. [36] End stage liver disease models also include hyperbilirubinemia as a critical parameter in prognosis of cirrhosis. Moreover, serum bilirubin is positively associated with mortality in patients with severe sepsis or traumatic brain injury.
Hereditary hyperbilirubinemia refers to a group of conditions where levels of bilirubin, a byproduct of red blood cell metabolism, are elevated in the blood due to a genetic cause. [1] Various mutations of enzymes in the liver cells, which breakdown bilirubin, cause varying elevated levels of bilirubin in the blood. [2]
In acute viral hepatitis, the GGT levels can peak at 2nd and 3rd week of illness, and remained elevated at 6 weeks of illness. GGT is also elevated in 30% of the hepatitis C patients. GGT can increase by 10 times in alcoholism. GGT can increase by 2 to 3 times in 50% of the patients with non-alcoholic liver disease. When GGT levels is elevated ...
High at birth or rapidly rising bilirubin [1] Prolonged hyperbilirubinemia [1] Bilirubin Induced Neurological Dysfunction [2] Cerebral Palsy [3] Kernicterus [4] Neutropenia [5] [6] Thrombocytopenia [5] Hemolytic Anemia - MUST NOT be treated with iron [7] Late onset anemia - Must NOT be treated with iron. Can persist up to 12 weeks after birth ...
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels. [3] [6] Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. [7]
People with GS predominantly have elevated unconjugated bilirubin, while conjugated bilirubin is usually within the normal range or is less than 20% of the total. Levels of bilirubin in GS patients are reported to be from 20 μM to 90 μM (1.2 to 5.3 mg/dl) [38] compared to the normal amount of < 20 μM. GS patients have a ratio of unconjugated ...
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High at birth or rapidly rising bilirubin [2] Prolonged hyperbilirubinemia [2] Bilirubin Induced Neuorlogical Dysfunction [3] Cerebral Palsy [4] Kernicterus [5] Neutropenia [6] [7] Thrombocytopenia [6] Hemolytic Anemia - MUST NOT be treated with iron [8] Late onset anemia - Must NOT be treated with iron. Can persist up to 12 weeks after birth ...