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To make a diagnosis of schizophrenia other possible causes of psychosis need to be excluded. [176]: 858 Psychotic symptoms lasting less than a month may be diagnosed as brief psychotic disorder, or as schizophreniform disorder. Psychosis is noted in Other specified schizophrenia spectrum and other psychotic disorders as a DSM-5 category.
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Symptoms of schizophrenia often appear soon after puberty, when the brain is undergoing significant maturational changes. Some investigators believe that the disease process of schizophrenia begins prenatally, remains dormant until puberty, then follows a period of neural degeneration that causes the symptoms to subsequently emerge. [13]
'This will turn out to be the most important break in the disease,' the Broad Institute's director Eric Lander said.
This additional post-menopausal peak of late-onset schizophrenia in women calls into question the etiology of the disease and raises a debate about "subtypes" of schizophrenia, with men and women being susceptible to different types (see causes of schizophrenia). This is further supported by the variability in presentation of the disease ...
In McGorry’s conception, schizophrenia goes through a “prodrome” stage when symptoms gradually emerge, a “first episode” phase that covers, on average, the two years before the first break and finally a “chronic” phase when the disease causes a steady deterioration in many patients that can be difficult if not impossible to reverse.
Symptoms of schizophrenia simplex include an absence of will, impoverished thinking and flattening of affect. There is a gradual deterioration of functioning with increased amotivation and reduced socialization. [6] [7] It is considered to be rarely diagnosed and is a schizophrenia without psychotic symptoms. [8]
The untreated symptoms of schizophrenia, exacerbated by limited access to health care, ensnare individuals in a relentless cycle of instability, hindering their ability to secure housing and ...
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