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An amygdala hijack is an emotional response that is immediate, overwhelming, and out of measure with the actual stimulus because it has triggered a much more significant emotional threat. [1] The term, coined by Daniel Goleman in his 1996 book Emotional Intelligence: Why It Can Matter More Than IQ , [ 2 ] is used by affective neuroscientists ...
The amygdala is known to have a role in the "fight-or-flight response", and the hippocampus functions to form memories of the stimulus and the emotions associated with it. [13] The role of the BNST in the acoustic startle reflex may be attributed to specific areas within the nucleus responsible for stress and anxiety responses. [ 12 ]
Amygdalotomy, also known as amygdalectomy, is a form of psychosurgery which involves the surgical removal or destruction of the amygdala, or parts of the amygdala.It is usually a last-resort treatment for severe aggressive behavioral disorders and similar behaviors including hyperexcitability, violent outbursts, and self-mutilation.
In fear conditioning, the main circuits that are involved are the sensory areas that process the conditioned and unconditioned stimuli, certain regions of the amygdala that undergo plasticity (or long-term potentiation) during learning, and the regions that bear an effect on the expression of specific conditioned responses.
Treatment guidelines note EMDR effectiveness is statistically the same as trauma-focused behavioral therapy, and the Australian National Health and Medical Research Council notes that this may be due to including most of the core elements of cognitive behavioral therapy (CBT).
Antidepressant treatment appears to reverse mood congruent biases in limbic, prefrontal, and fusiform areas. dlPFC response is enhanced and amygdala response is attenuated during processing of negative emotions, the former of which is thought to reflect increased top down regulation.
Regardless of directionality of amygdala abnormalities, as the amygdala plays a central role in emotional systems, these findings support dysfunctional emotional circuits in bipolar. A general reduction in ventrolateral prefrontal cortex activity is observed in bipolar, and is lateralized with regard to mood (i.e., left-depression, right-mania ...
Guanfacine does not appear to be effective for improving sleep in children with ADHD and behavioral insomnia. [31] Instead, guanfacine worsened certain sleep parameters, for instance total sleep time, in one clinical trial. [31] [32] Guanfacine has been investigated for treatment of withdrawal for opioids, ethanol, and nicotine. [67]