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Telomeric repeat-binding factor 2 is a protein that is present at telomeres throughout the cell cycle. It is also known as TERF2, TRF2, and TRBF2, and is encoded in humans by the TERF2 gene. [ 5 ] It is a component of the shelterin nucleoprotein complex and a second negative regulator of telomere length, playing a key role in the protective ...
The telomeric repeat binding factor 1 protein is present at telomeres, where the cells aging aspect is monitored, throughout the typical cell cycle process. [7] The progressive loss of the telomeric ends of chromosomes is an important mechanism in the timing of human cellular aging.
In particular, telomere-binding protein refers to TTAGGG repeat binding factor-1 and TTAGGG repeat binding factor-2 . [1] Telomere sequences in humans are composed of TTAGGG sequences which provide protection and replication of chromosome ends to prevent degradation. Telomere-binding proteins can generate a T-loop to protect chromosome ends. [2]
TRF2 (Telomere Repeat binding Factor 2) TRF2 is structurally related to TRF1, and helps to form T-loops. [6] TRF2 is a homodimeric protein [1] that binds to the double-stranded TTAGGG region of the telomere and prevents the recognition of double-strand DNA breaks. [17] Overexpression of TRF2 leads to telomere shortening. [6]
Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the TERF2IP gene. [ 5 ] [ 6 ] Interactions
Telomeric repeat–containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that function to protect DNA from deterioration or fusion with neighboring chromosomes. TERRA has been shown to be ubiquitously expressed in almost all cell types containing linear ...
Terminal restriction fragments, used in measuring telomere length; Thyrotropin-releasing factor, a peptide hormone secreted by the hypothalamus; Time-restricted feeding, a type of intermittent fasting; Transfer RNA-derived fragment; TERF1, Telomeric repeat-binding factor 1 (also known as TRF1)
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component that serves as a template for the telomere repeat.