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In addition, factors such as rapid infusion, concurrent use of more than one drug known to prolong QT interval, diuretic treatment, electrolyte derangements (hypokalemia, hypomagnesemia, or hypocalcemia), advanced age, bradyarrhythmias, and female sex have all been shown to be risk factors for developing drug-induced QT prolongation. [2]
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
Common side effects ... Defibrillation is the treatment of choice for ... since amiodarone may cause bradycardia and QTc prolongation which can affect exercise ...
Cardiac repolarization; QT interval prolongation. [2] Hydromorphone (Palladone, extended release version) 2005 High risk of accidental overdose when extended release version (Palladone) administered with alcohol. Standard hydromorphone is sold in most of the world including the US Ibufenac: 1968 UK Hepatotoxicity, jaundice. [3] Indalpine: 1985 ...
Common side effects include constipation, headache, nausea, and dizziness. [5] Serious side effects may include QT prolongation. [5] Ranolazine is contraindicated (not recommended) in those with liver cirrhosis. [5] How it works is not clear but may involve adenosine triphosphate. [5] Ranolazine was approved for medical use in the United States ...
The effect of quinidine on the ion channels is to prolong the cardiac action potential, thereby prolonging the QT interval on the surface ECG. Other ECG effects include a wide notched P wave, wide QRS complex, depressed ST segment, and U waves. These are the results of both slowed depolarization and repolarization.
Dolasetron is a well-tolerated drug with few side effects. Headache, dizziness, and constipation are the most commonly reported side effects associated with its use. There is a potential for prolonging of the QT interval to occur as well. There have been no significant drug interactions reported with this drug's use.
The drug also increases the QT interval and liver enzymes (alanine transaminase, aspartate transaminase). [4] [9] The most common side effects include infections, low levels of white blood cells, headache, cough, nausea (feeling sick), vomiting, diarrhoea, constipation, tiredness, hair loss and rash. [5]