Search results
Results from the WOW.Com Content Network
In non-adipocytes, lipid storage, lipid droplet synthesis and lipid droplet growth can be induced by various stimuli including growth factors, long-chain unsaturated fatty acids (including oleic acid and arachidonic acid), oxidative stress and inflammatory stimuli such bacterial lipopolysaccharides, various microbial pathogens, platelet ...
In lipotoxic cells, there is an imbalance between the amount of lipids produced and the amount used. Upon entrance of the cell, fatty acids can be converted to different types of lipids for storage. Triacylglycerol consists of three fatty acids bound to a glycerol molecule and is considered the most neutral and harmless type of intracellular ...
Perilipin, also known as lipid droplet-associated protein, perilipin 1, or PLIN, is a protein that, in humans, is encoded by the PLIN gene. [5] The perilipins are a family of proteins that associate with the surface of lipid droplets. Phosphorylation of perilipin is essential for the mobilization of fats in adipose tissue. [6]
The formation and breakdown of lipid droplets is controlled by various enzymes and lipid droplet-associated proteins. One of the lipid droplet-associated proteins is HILPDA. HILPDA acts as a regulatory signal that blocks the breakdown of the fat stores in cells when the external fat supply is high or the availability of oxygen is low. In cells ...
Antiretroviral therapy, the most common treatment for patients with HIV, has been shown to restore CD4+ T cell counts. [20] The body responds to T cell depletion by producing an equal amount of T cells. However, over time, an individual's immune system can no longer continue to replace CD4+ T cells. [21] This is called the "tap and drain ...
Now, having lipid deposits in the white blood cells of the individual is known and recognized as Jordans' anomaly, due to the medical professional who discovered it. [10] The first case of neutral lipid storage disease was reported by Maurice Dorfman when he treated two sisters with non-bullous ichthyosiform erythroderma in 1974. [2]
The lipid droplet's function is to store energy for the organism's body and is found in every type of adipocytes. They can consist of a vacuole, droplet of triglyceride, or any other blood lipid, as opposed to fat cells in between other cells in an organ. They contain a hydrophobic core and are encased in a phospholipid monolayer membrane. Due ...
The perilipin family contributes to the creation of lipid droplets and it also plays a pivotal role in determining what the lipid droplet's function is within the cell. [12] In addition, perilipin 5 regulates the activation of hepatic stellate cell , implicated in fibrosis , which is the creation of new tissue to repair the one damaged.