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Nitroglycerin (NG) (alternative spelling nitroglycerine), also known as trinitroglycerol (TNG), nitro, glyceryl trinitrate (GTN), or 1,2,3-trinitroxypropane, is a dense, colorless or pale yellow, oily, explosive liquid most commonly produced by nitrating glycerol with white fuming nitric acid under conditions appropriate to the formation of the nitric acid ester.
Nitroglycerin was written about as early as 1846 [5] [6] and came into medical use in 1878. [7] [8] [9] The drug nitroglycerin is a dilute form of the same chemical used as the explosive, nitroglycerin. [9] Dilution makes it non-explosive. [9]
First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.
Some guys might feel the effects of Viagra faster when they take the pill on an empty stomach. Taking it with food, particularly high-fat foods like a burger and fries, can slow it down or even ...
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Died of apparent dysentery in June, after a months-long period of illness during which he predicted his own imminent death, in his 46th year. 1422: King Henry V of England died suddenly on 31 August 1422 at the Château de Vincennes, apparently from dysentery, [39] which he had contracted during the siege of Meaux. He was 35 years old and had ...
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This nitrite is swallowed and reacts with acid and reducing substances in the stomach (such as ascorbate) to produce high concentrations of nitric oxide. The purpose of this mechanism to create NO is thought to be both sterilization of swallowed food (to prevent food poisoning) and to maintain gastric mucosal blood flow. [12]
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