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They show activity at serotonin 5-HT 1-2, dopamine D2-like and alpha1/alpha2-adrenoreceptors. [4] Their lack of selectivity leads to more adverse effects, making them second line compared to triptans. [4] However, they have been shown to prevent recurrence better than triptans. [5] Adverse effects include nausea, vomiting, paresthesia, and ...
Rizatriptan, sold under the brand name Maxalt among others, is a medication used for the treatment of migraine headaches. [1] [3] It is taken by mouth. [1] [3] It can also be applied on the tongue. [2] It is a serotonin (5-HT) 1B/1D receptor agonist (triptan). [1] [2] Common side effects include chest pain, dizziness, dry mouth, and tingling. [3]
Triptans have few side effects if used in correct dosage and frequency. The most common adverse effect is recurrence of migraine. A systematic review found that "rizatriptan 10 mg was the only triptan with a recurrence rate greater than that of placebo". [24]
Side effects are similar to other triptan medications, with the incidence of side effects reportedly being lower than sumatriptan, and side effects occurring rarely except when above 2.5mg. [ 5 ] [ 6 ] The risk of triptan side effects is also in general low, according to a systematic review. [ 7 ]
The most common side effects [14] reported by at least 2% of patients in controlled trials of sumatriptan (25-, 50-, and 100-mg tablets) for migraine are atypical sensations (paresthesias and warm/cold sensations) reported by 4% in the placebo group and 5–6% in the sumatriptan groups, pain and other pressure sensations (including chest pain ...
As with other triptans, almotriptan should not be used in patients with a history, symptoms or signs of ischaemic heart disease (myocardial infarction, angina pectoris, documented silent ischaemia, Prinzmetal's angina) or severe hypertension and uncontrolled mild or moderate hypertension.
Eletriptan is a serotonin receptor agonist, specifically an agonist of certain 5-HT 1 family receptors. Eletriptan binds with high affinity to the 5-HT [1B , 1D , 1F] receptors. It has a modest affinity to the 5-HT [1A , 1E , 2B , 7] receptors, and little to no affinity at the 5-HT [2A , 2C , 3 , 4 , 5A , 6] receptors.
Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches. They are selective 5-hydroxytryptamine/serotonin 1B/1D (5-HT 1B/1D) agonists. [1] Migraine is a complex disease which affects about 15% of the population and can be highly disabling. [2]
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