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Cancer is caused by genetic changes leading to uncontrolled cell growth and tumor formation. The basic cause of sporadic (non-familial) cancers is DNA damage and genomic instability. [1] [2] A minority of cancers are due to inherited genetic mutations. [3] Most cancers are related to environmental, lifestyle, or behavioral exposures. [4]
World-wide, liver cancer is the 4th most frequent cause of cancer mortality, causing 9% of all cancer mortality (total liver cancer deaths in 2015 being 810,500), and coming, in frequency, after lung, colorectal and stomach cancers. [34]
In the U.S. cancer is second only to cardiovascular disease as the leading cause of death; [20] in the UK it is the leading cause of death. [21] In many developing countries cancer incidence, insofar as this can be measured, appears much lower, most likely because of the higher death rates due to infectious disease or injury.
Similarly, cancer has long been, and remains, one of the top two leading causes of death. More than 613,000 people died from the disease last year. More than 613,000 people died from the disease ...
In 2022, breast cancer remained the most commonly diagnosed cancer in women globally, and the leading cause of cancer death, according to the IARC. Lung and colorectal cancers were the second and ...
A report from the American Cancer Society especially highlighted colorectal cancer, which is now the leading cause of cancer death in men younger than 50 and the second in women under 50.
Since 1% to 3% of infected individuals are likely to develop gastric cancer, [109] H. pylori-induced gastric cancer is the third highest cause of worldwide cancer mortality as of 2018. [110] Infection by H. pylori causes no symptoms in about 80% of those infected. [111] About 75% of individuals infected with H. pylori develop gastritis. [112]
For example, various Global Burden of Disease Studies investigate such factors and quantify recent developments – one such systematic analysis analyzed the (non)progress on cancer and its causes during the 2010–19-decade, indicating that 2019, ~44% of all cancer deaths – or ~4.5 M deaths or ~105 million lost disability-adjusted life years ...