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Brain regions like the dorsolateral prefrontal cortex and orbitofrontal cortex, which are involved in pain perception and coping, are often altered in those with chronic pain. These changes are especially pronounced in the Default Mode Network, which plays a key role in working memory and emotional regulation, further impacting pain management ...
Depression and pain often co-occur. One or more pain symptoms are present in 65% of people who have depression, and anywhere from 5 to 85% of people who are experiencing pain will also have depression, depending on the setting—a lower prevalence in general practice, and higher in specialty clinics.
Stress can cause depression and depression-like symptoms through monoaminergic changes in several key brain regions as well as suppression in hippocampal neurogenesis. [118] This leads to alteration in emotion and cognition related brain regions as well as HPA axis dysfunction.
People with depression may be more prone to experiencing period pain, potentially due to genetic factors in part, a new study has found. Study reveals ‘strong genetic connection’ between ...
Scientists may be a step closer to that reality, thanks to new research that has identified six subtypes — or “biotypes” — of major depression via brain imaging combined with machine learning.
This pain can also be caused by psychological disorders such as anxiety and depression, which can affect the onset and severity of pain experienced. The International Association for the Study of Pain (IASP) defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential ...
Neuropathic pain has profound physiological effects on the brain which can manifest as psychological disorders. Rodent models where the social effects of chronic pain can be isolated from other factors suggest that induction of chronic pain can cause anxio-depressive symptoms and that particular circuits in the brain have a direct connection.
Chest pain can be a symptom of anxiety, so if chest pain was occurring before the sertraline was started, it’s probably the anxiety, not the medication. It’s important to point out that this ...
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