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Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isoform") that has been found only in mammals. IgE is synthesised by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing four Ig-like constant domains (Cε1–Cε4). [1]
n/a Ensembl ENSG00000211891 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.6 – 105.6 Mb n/a PubMed search n/a Wikidata View/Edit Human Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene. Function IGHE (Immunoglobulin Heavy constant Epsilon), (located on chromosome 14 for humans) has been predicted to enable ...
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. [1]
Immunoglobulin E is a class of antibody (or immunoglobulin "isotype") that has only been found in mammals. It plays an important role in allergy, and is especially associated with type 1 hypersensitivity. There are receptors (FcεR) for the constant region of IgE, the Fc region, on several types of cells, including Mast cells and Basophils ...
Omalizumab is the drug therapy used to deliver the anti-immunoglobulin E antibodies. Omalizumab is a human anti-IgE monoclonal antibody. It blocks IgE-mediated reactions and reduces asthma symptoms by binding to free IgE antibodies in serum. The drug is delivered every 2-4 weeks depending on severity of the patient.
An IgE level greater than 2,000 IU/mL is often considered diagnostic. [17] However, patients younger than 6 months of age may have very low to non-detectable IgE levels. Eosinophilia is also a common finding with greater than 90% of patients having eosinophil elevations greater than two standard deviations above the normal mean. [ 18 ]
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