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Kidney stone disease, also known as renal calculus disease, nephrolithiasis or urolithiasis, is a crystallopathy where a solid piece of material (renal calculus) develops in the urinary tract. [2] Renal calculi typically form in the kidney and leave the body in the urine stream. [2] A small calculus may pass without causing symptoms. [2]
After experiencing pains in his side for several days, Dr. Eric Topol decided to try his hand at a self-diagnosis.
The urine test strip test for blood is based on hemoglobin's pseudo peroxidase activity in catalysing a reaction between hydrogen peroxide and the chromogen tetramethylbenzidine in order to produce a dark blue oxidation product. [6] [13] the resultant colour can vary between green and dark blue depending on the amount of hemoglobin. [13]
Many stone types can be detected by ultrasound; Factors contributing to stone formation (as in #Etiology) are often tested: Laboratory testing can give levels of relevant substances in blood or urine; Some stones can be directly recovered (at surgery, or when they leave the body spontaneously) and sent to a laboratory for analysis of content
Kidney stones are caused by high levels of the minerals calcium, oxalate, and phosphorus in urine. These minerals are normally found in urine and do not cause problems at low levels.
Additionally, hypercalciuria can contribute to kidney stone formation which may present with flank or back pain that comes and goes. It can be painful to pass kidney stones and in extreme cases cause kidney damage. [2] [3] Patients that both form kidney stones and have hypercalciuria are at increased risk for bone loss leading to osteoporosis. [4]
[16] [17] [18] All stones are detectable on CT scans except very rare stones composed of certain drug residues in the urine. [19] In patients with recurrent ascending urinary tract infections, it may be necessary to exclude an anatomical abnormality, such as vesicoureteral reflux or polycystic kidney disease.
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