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An epinephrine autoinjector (or adrenaline autoinjector, also known by the trademark EpiPen) is a medical device for injecting a measured dose or doses of epinephrine (adrenaline) by means of autoinjector technology. It is most often used for the treatment of anaphylaxis. The first epinephrine autoinjector was brought to market in 1983.
The commonly used epinephrine autoinjector delivers a 0.3 mg epinephrine injection (0.3 mL, 1:1000). [citation needed] It is indicated in the emergency treatment of allergic reactions, including anaphylaxis to stings, contrast agents, medicines, or people with a history of anaphylactic reactions to known triggers.
Adrenaline, also known as epinephrine, is a hormone and medication [10] [11] which is involved in regulating visceral functions (e.g., respiration). [10] [12] It appears as a white microcrystalline granule. [13] Adrenaline is normally produced by the adrenal glands and by a small number of neurons in the medulla oblongata. [14]
This is a list of mnemonics used in medicine and medical science, categorized and alphabetized. A mnemonic is any technique that assists the human memory with information retention or retrieval by making abstract or impersonal information more accessible and meaningful, and therefore easier to remember; many of them are acronyms or initialisms which reduce a lengthy set of terms to a single ...
Alpha adrenoreceptor ligands mimic the action of epinephrine and norepinephrine signaling in the heart, smooth muscle and central nervous system, with norepinephrine being the highest affinity. The activation of α 1 stimulates the membrane bound enzyme phospholipase C , and activation of α 2 inhibits the enzyme adenylate cyclase .
Extracts of unripe fruit from Asian cultivars of Citrus aurantium (commonly known as "bitter" orange), collected in China, were reported to contain synephrine levels of about 0.1–0.3%, or ~1–3 mg/g; [10] Analysis of dried fruit of C. aurantium grown in Italy showed a concentration of synephrine of ~1 mg/g, with peel containing over three times more than the pulp.
Sodium metabisulfite is added as an excipient to medications which contain adrenaline (epinephrine), in order to prevent the oxidation of adrenaline. [6] For example, it is added to combination drug formulations which contain a local anaesthetic and adrenaline, [ 6 ] and to the formulation in epinephrine autoinjectors , such as the EpiPen. [ 7 ]
[36] [38] The specific degrees of inhibition after 4 weeks were 99.4% with 10 mg/day, 99.5% with 5 mg/day, 96.0% with 10 mg twice per week, and 75.9% with 10 mg once per week, respectively. [38] On the basis of these findings, it was concluded that 20 mg per week (as 10 mg twice per week) is the minimum dosage that can produce maximal and long ...