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Vascular endothelial growth factor (VEGF, / v ɛ dʒ ˈ ɛ f /), originally known as vascular permeability factor (VPF), [1] is a signal protein produced by many cells that stimulates the formation of blood vessels.
Vascular endothelial growth factor A (VEGF-A) is a dimeric glycoprotein that plays a significant role in neurons and is considered to be the main, dominant inducer of the growth of blood vessels. VEGFA is essential for adults during organ remodeling and diseases that involve blood vessels, for example, in wound healing, tumor angiogenesis ...
22341 Ensembl ENSG00000150630 ENSMUSG00000031520 UniProt P49767 P97953 RefSeq (mRNA) NM_005429 NM_009506 RefSeq (protein) NP_005420 NP_033532 Location (UCSC) Chr 4: 176.68 – 176.79 Mb Chr 8: 54.53 – 54.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular ...
Overexpression of VEGF causes increased permeability in blood vessels in addition to stimulating angiogenesis. In wet macular degeneration, VEGF causes proliferation of capillaries into the retina. Since the increase in angiogenesis also causes edema, blood and other retinal fluids leak into the retina, causing loss of vision. Anti-angiogenic ...
VEGF normally targets endothelial cells and causes an increase in vascular permeability that is both fast and reversible. Increased VEGF could explain several clinical features of POEMS, including organomegaly , edema , skin abnormalities , and neuropathy , as well as increasing microvascular permeability of blood vessels with endoneurial edema.
22340 Ensembl ENSG00000173511 ENSMUSG00000024962 UniProt P49765 P49766 RefSeq (mRNA) NM_003377 NM_001243733 NM_001185164 NM_011697 RefSeq (protein) NP_001230662 NP_003368 NP_001172093 NP_035827 Location (UCSC) Chr 11: 64.23 – 64.24 Mb Chr 19: 6.96 – 6.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Vascular endothelial growth factor B also known as VEGF-B is a protein that, in ...
In the wet form, anti–vascular endothelial growth factor injected into the eye or, less commonly, laser coagulation or photodynamic therapy may slow worsening. [1] Dietary antioxidant vitamins, minerals, and carotenoids do not appear to affect the onset; [5] however, dietary supplements may slow the progression in those who already have the ...
As hCG causes the ovary to undergo extensive luteinization, large amounts of estrogens, progesterone, and local cytokines are released. It is almost certain that vascular endothelial growth factor (VEGF) is a key substance that induces vascular hyperpermeability, making local capillaries "leaky", leading to a shift of fluids from the ...