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In medicine, myopathy is a disease of the muscle [1] in which the muscle fibers do not function properly. Myopathy means muscle disease (Greek : myo- muscle + patheia -pathy : suffering). This meaning implies that the primary defect is within the muscle, as opposed to the nerves ("neuropathies" or "neurogenic" disorders) or elsewhere (e.g., the ...
Inflammatory myopathy, also known as idiopathic inflammatory myopathy (IIM), is disease featuring muscle weakness, inflammation of muscles , and in some types, muscle pain . The cause of much inflammatory myopathy is unknown ( idiopathic ), and such cases are classified according to their symptoms and signs , electromyography , MRI , and ...
Acquired non-inflammatory myopathy (ANIM) is a neuromuscular disorder primarily affecting skeletal muscle, most commonly in the limbs of humans, resulting in a weakness or dysfunction in the muscle. [1] A myopathy refers to a problem or abnormality with the myofibrils, which compose muscle tissue.
Dermatomyositis is a form of systemic connective tissue disorder, a class of diseases that often involves autoimmune dysfunction. [ 12 ] [ 16 ] It has also been classified as an idiopathic inflammatory myopathy , along with polymyositis, necrotizing autoimmune myositis, cancer-associated myositis , and sporadic inclusion body myositis .
The idea behind the "mixed" disease is that this specific autoantibody is also present in other autoimmune diseases such as systemic lupus erythematosus, polymyositis, scleroderma, etc. MCTD was characterized as an individual disease in 1972 by Sharp et al., [3] [4] and the term was introduced by Leroy [5] in 1980.
However, other inflammatory conditions, such as lupus, can have a positive anti-NT5C1A. [1] As of 2019, it remains to be established whether a positive anti-NT5C1A antibody test can make muscle biopsy unneeded. [1] Inclusion body myositis MRI. Muscle imaging can help establish the pattern of muscle involvement and selection of a biopsy site. [1]
Myositis is a rarely-encountered medical condition characterized by inflammation affecting the muscles. [2] The manifestations of this condition may include skin issues, muscle weakness, and the potential involvement of other organs. [3]
Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people who take statin medications. [1] However, there are cases of SAAM in patients who have not taken statin medication, and this can be explained by the exposure to natural sources of statin ...