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Allele frequency. Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. [1] Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size.
Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. [2] In population genetics, the genotype frequency is the frequency or proportion (i.e., 0 < f < 1) of genotypes in a population. Although allele and genotype frequencies are related, it is ...
Genetic drift, also known as random genetic drift, allelic drift or the Wright effect, [ 1 ] is the change in the frequency of an existing gene variant (allele) in a population due to random chance. [ 2 ] Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation. [ 3 ]
1. Introduce the reference of a SNP of interest, as an example: rs429358, in a database (dbSNP or other). 2. Find MAF/MinorAlleleCount link. MAF/MinorAlleleCount: C=0.1506/754 (1000 Genomes, where number of genomes sampled = N = 2504); [4] where C is the minor allele for that particular locus; 0.1506 is the frequency of the C allele (MAF), i.e. 15% within the 1000 Genomes database; and 754 is ...
Frequency-dependent selection is an evolutionary process by which the fitness of a phenotype or genotype depends on the phenotype or genotype composition of a given population. In positive frequency-dependent selection, the fitness of a phenotype or genotype increases as it becomes more common. In negative frequency-dependent selection, the ...
SNP genotyping is the measurement of genetic variations of single nucleotide polymorphisms (SNPs) between members of a species. It is a form of genotyping, which is the measurement of more general genetic variation. SNPs are one of the most common types of genetic variation. An SNP is a single base pair mutation at a specific locus, usually ...
Genetic distance. Genetic distance is a measure of the genetic divergence between species or between populations within a species, whether the distance measures time from common ancestor or degree of differentiation. [ 2 ] Populations with many similar alleles have small genetic distances.
A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment. [2] These QTLs are often found on different chromosomes. The number of QTLs which explain variation in ...