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3β-Hydroxysteroid dehydrogenase/Δ 5-4 isomerase (3β-HSD) (EC 1.1.1.145) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.
Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...
Steroidogenesis. Steroid numbering. Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids.These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).
3β-HSD II mediates three parallel dehydrogenase/isomerase reactions in the adrenals that convert Δ 4 to Δ 5 steroids: pregnenolone to progesterone, 17α-hydroxypregnenolone to 17α-hydroxyprogesterone, and dehydroepiandrosterone (DHEA) to androstenedione. 3β-HSD II also mediates an alternate route of testosterone synthesis from androstenediol in the testes. 3β-HSD deficiency results in ...
The presence of neurofibrillary tangles in the brain is one of the key hallmarks of Alzheimer’s disease. These irregular clumps of protein are closely associated with disease progression.
3028 15108 Ensembl ENSG00000072506 ENSMUSG00000025260 UniProt Q99714 O08756 RefSeq (mRNA) NM_004493 NM_001037811 NM_016763 RefSeq (protein) NP_001032900 NP_004484 n/a Location (UCSC) Chr X: 53.43 – 53.43 Mb Chr X: 150.78 – 150.79 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a ...
On the occasion of the 10th anniversary of the Frida relaunch in the U.S., CEO Chelsea Hirschhorn looks back at the "blind naivete" that let her believe the snotsucker could go mainstream.
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