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MRI of the breasts has the highest sensitivity to detect breast cancer when compared with other imaging modalities such as breast ultrasound or mammography. In the screening for breast cancer for high-risk women, sensitivity of MRI ranges from 83 to 94% while specificity (the confidence that a lesion is cancerous and not a false positive ...
An early clinical trial examines MRI guided ablation to destroy early stage breast cancer tumors. People still need to undergo chemotherapy, radiation. Mom receives new procedure to remove breast ...
A specialized growing subset of interventional MRI is intraoperative MRI, in which an MRI is used in surgery. Some specialized MRI systems allow imaging concurrent with the surgical procedure. More typically, the surgical procedure is temporarily interrupted so that MRI can assess the success of the procedure or guide subsequent surgical work ...
As a free solubilized aqueous ion, gadolinium(III) is highly toxic, but the chelated compounds are generally regarded as safe for individuals without kidney disease. Free Gd 3+ has a median lethal dose of 0.34 mmol/kg (IV, mouse) [ 27 ] or 100–200 mg/kg, but the LD50 is increased by a factor of 31 times [ 28 ] when Gd 3+ is chelated.
Breast ultrasound is another technology employed in diagnosis and screening that can help differentiate between fluid filled and solid lesions, an important factor to determine if a lesion may be cancerous. [2] Breast MRI is a technology typically reserved for high-risk patients and patients recently diagnosed with breast cancer. [3]
Breast density is assessed by mammography and expressed as a percentage of the mammogram occupied by radiologically dense tissue (percent mammographic density or PMD). [23] About half of middle-aged women have dense breasts, and breasts generally become less dense as they age. Higher breast density is an independent risk factor for breast cancer.
MRI without contrast agents is the imaging mode of choice for pre-surgical, in-utero diagnosis and evaluation of fetal tumors, primarily teratomas, facilitating open fetal surgery, other fetal interventions, and planning for procedures (such as the EXIT procedure) to safely deliver and treat babies whose defects would otherwise be fatal.
In patients where MRI is contraindicated (certain implantable devices, certain kidney conditions) or in those who prefer to avoid MRI (claustrophobia), molecular breast imaging is a viable alternative. MBI has shown to increase detection of breast cancer in dense breasts by 7-16 cancers per 1000 screens. [1] [3] [5]
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