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Homocysteine thiolactone (HTL) is an organosulfur compound with the formula H 2 NCHC(O)SCH 2 CH 2. It is the thiolactone (intramolecular thioester ) of homocysteine . It is produced by methionyl-tRNA synthetase in an error-editing reaction that prevents translational incorporation of homocysteine into proteins .
Homocysteine can cyclize to give homocysteine thiolactone, a five-membered heterocycle. Because of this "self-looping" reaction, homocysteine-containing peptides tend to cleave themselves by reactions generating oxidative stress. [12] Homocysteine also acts as an allosteric antagonist at Dopamine D 2 receptors. [13]
The activation of the drug clopidogrel (top left) gives a thiolactone, which ring-opens. [3] Thiolactones are intermediates in the activation of some drugs. [4] In nature, the most common thiolactone is homocysteine thiolactone. It is produced from homocysteine. It may play a role in protein damage. [5]
Homocysteine thiolactone; K. Kadethrin This page was last edited on 3 January 2014, at 21:25 (UTC). Text is available under the Creative Commons ...
The required homocysteine is synthesized from methionine in reactions 1, 2, and 3. The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine through the intermediate cystathionine. Two transsulfurylation pathways are known: the forward and the reverse. [1]
Homocysteine thiolactone; I. 2-Iminothiolane; K. Kadethrin; T. Tetrahydrothiophene This page was last edited on 16 July 2021, at 16:50 (UTC). Text is available under ...
Deficiencies of vitamin B 12 or folate cause increased levels of circulating homocysteine. Elevated homocysteine is a risk factor for cardiovascular disease and is linked to the metabolic syndrome (insulin insensitivity). [1] Transmethylation is decreased sometimes in parents of children with autism. [2]
642 104184 Ensembl ENSG00000108578 ENSMUSG00000020840 UniProt Q13867 Q8R016 RefSeq (mRNA) NM_000386 NM_178645 RefSeq (protein) NP_000377 NP_848760 Location (UCSC) Chr 17: 30.25 – 30.29 Mb Chr 11: 76.82 – 76.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene. Bleomycin hydrolase (BMH) is a cytoplasmic ...
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