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Activating Protein 2 (AP-2) is a family of closely related transcription factors [1] [2] which plays a critical role in regulating gene expression during early development. [ 3 ] References
Mutations in the AP-2 alpha gene also cause branchio-oculo-facial syndrome, [19] which has overlapping features with Van der Woude syndrome such as orofacial clefting and occasional lip pits what make rs642961 a good candidate for an etiological variant. These findings show that IRF6 and AP-2 alpha are in the same developmental pathway and ...
Advanced Placement (AP) Physics 2 is a year-long introductory physics course administered by the College Board as part of its Advanced Placement program. It is intended to proxy a second-semester algebra-based university course in thermodynamics, electromagnetism, optics, and modern physics. [1]
Gene Ontology is being used by researchers to establish a disease-gene relationship, as GO helps in the identification of novel genes, the alterations in their expression, distribution and function under a different set of conditions, such as diseased versus healthy. [41]
Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. [5] AP2-gamma is a member of the activating protein 2 family of transcription factors. Transcription factor AP-2 gamma is involved in early development, specifically morphogenesis - the formation of shape.
Ab Initio gene prediction is an intrinsic method based on gene content and signal detection. Because of the inherent expense and difficulty in obtaining extrinsic evidence for many genes, it is also necessary to resort to ab initio gene finding, in which the genomic DNA sequence alone is systematically searched for certain tell-tale signs of protein-coding genes.
AP-2 beta is a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development.
In the genomic branch of bioinformatics, homology is used to predict the function of a gene: if the sequence of gene A, whose function is known, is homologous to the sequence of gene B, whose function is unknown, one could infer that B may share A's function. In structural bioinformatics, homology is used to determine which parts of a protein ...