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Brotizolam [3] (marketed under brand name Lendormin) is a sedative-hypnotic [4] thienotriazolodiazepine [5] drug which is a benzodiazepine analog. [6] It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, and is considered to be similar in effect to other short-acting hypnotic benzodiazepines such as triazolam or midazolam. [7]
Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl) piperazin-1-ylmethyl]-cyclohexylmethyl}-hexahydro-4,7-methano-2Hisoindole-1,3-dione hydrochloride]] [70] is an azapirone derivative [71] and acts as an antagonist of the dopamine D 2 and D 3 receptors, [72] and the serotonin 5-HT 2A and 5-HT 7 receptors, and the α 2C ...
RR 4.9 CI 2.3 to 10.4: Very low (estimate of effect uncertain) Sedation: 3 times more likely to cause sedation, around 30% with chlorpromazine: RR 2.8 CI 2.3 to 3.5 Acute movement disorder: 3.5 times more likely to cause easily reversible but unpleasant severe stiffening of muscles, around 6% with chlorpromazine: RR 3.5 CI 1.5 to 8.0 Parkinsonism
Oclacitinib lacks the side effects that most JAK inhibitors have in humans; instead, side effects are infrequent, mild, and mostly self-limiting. [13] [14] [16] The most common side effects are gastrointestinal problems (vomiting, diarrhea, and appetite loss) and lethargy. The GI problems can sometimes be alleviated by giving oclacitinib with food.
Serious side effects may include cardiac arrest, arrhythmias, and heart failure. [1] It may be used in pregnancy, but has not been well studied in this population. [3] [4] Use is not recommended in those with structural heart disease or ischemic heart disease. [1] Flecainide is a class Ic antiarrhythmic agent. [1]
Levetiracetam, sold under the brand name Keppra among others, is a novel antiepileptic drug [7] used to treat epilepsy. [8] It is used for partial-onset, myoclonic, or tonic–clonic seizures, [7] and is taken either by mouth as an immediate or extended release formulation or by injection into a vein.
Common side effects include headache, ... 1.3 5.6 Antagonist M 1: 7.9 30 Antagonist M 2: High ND: ... A 2004 review found benefit for fibromyalgia symptoms, ...