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Generic 100 mg doxycycline capsules A package of generic doxycycline. In addition to the general indications for all members of the tetracycline antibiotics group, doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease, [13] [14] severe acne, rosacea, [15] [16] [17] and rickettsial infections. [18]
A hyclate (Latin: hyclas) is a pharmaceutical term for hydrochloride hemiethanolate hemihydrate [1] [2] (·HCl· 1 / 2 EtOH· 1 / 2 H 2 O), e.g. doxycycline hyclate. [ 3 ] [ 4 ] References
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
Other side effects include poor tooth development if used by children less than eight years of age, kidney problems, and sunburning easily. [3] Use during pregnancy may harm the baby. [3] It works by inhibiting protein synthesis in bacteria. [3] Tetracycline was patented in 1953 [6] and was approved for prescription use in 1954.
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Minocycline, sold under the brand name Minocin among others, is a tetracycline antibiotic medication used to treat a number of bacterial infections such as some occurring in certain forms of pneumonia. [2] [4] [8] It is generally (but not always) less preferred than the tetracycline doxycycline.
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It is used as a precursor in the industrial synthesis of doxycycline hyclate. [citation needed] It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro. [1]
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