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Therefore, a drug given by the intravenous route will have an absolute bioavailability of 100% (f = 1), whereas drugs given by other routes usually have an absolute bioavailability of less than one. If we compare the two different dosage forms having same active ingredients and compare the two drug bioavailability is called comparative ...
2.4 Oral mucosal. 2.4.1 Buccal. 2.4.2 ... a route of administration is the ... They also have essentially 100% bioavailability and can be used for drugs that are ...
Absorption by some other routes, such as intravenous therapy, intramuscular injection, enteral nutrition, is even more straightforward and there is less variability in absorption and bioavailability is often near 100%. Intravascular administration does not involve absorption, and there is no loss of drug. [4]
[2] [27] In addition, while a 60 mg dose has no effect on testosterone levels in men, this dose does measurably increase testosterone levels in prepubertal boys and women. [27] The oral bioavailability of testosterone in young women after a single 25 mg dose was found to be 3.6 ± 2.5%. [ 29 ]
Therefore, if a drug has a bioavailability of 0.8 (or 80%) and it is administered in a dose of 100 mg, the equation will demonstrate the following: De = 0.8 × 100 mg = 80 mg. That is the 100 mg administered represents a blood plasma concentration of 80 mg that has the capacity to have a pharmaceutical effect.
The systemic bioavailability of ziprasidone is 100% when administered intramuscularly and 60% when administered orally without food. [ 3 ] After a single dose intramuscular administration, the peak serum concentration typically occurs at about 60 minutes after the dose is administered, or earlier. [ 48 ]
Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. [1] [2] It is used together with a diabetic diet and exercise. [1] [2] It is not indicated for use by itself in type 1 diabetes. [1] [2] It is taken by mouth.
[2] [1] [3] It is a derivative of estradiol with a bridge between the C14α and C17α positions. [2] [1] [3] [4] Cyclodiol has 100% of the relative binding affinity of estradiol for the human ERα and similar transactivational capacity as estradiol at the receptor. [2] It has comparable potency to estradiol when administered by subcutaneous ...