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Smallpox is the first disease, and so far the only infectious disease of humans, to be eradicated by deliberate intervention. [6] It became the first disease for which there was an effective vaccine in 1798 when Edward Jenner showed the protective effect of inoculation (vaccination) of humans with material from cowpox lesions. [10]
Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus. [7] [11] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, [10] making smallpox the only human disease to have been eradicated to date.
The smallpox vaccine is used to prevent smallpox infection caused by the variola virus. [10] It is the first vaccine to have been developed against a contagious disease. In 1796, British physician Edward Jenner demonstrated that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus.
The words come from various (spotted) or varus (pimple). In England, this disease was first known as the "pox" or the "red plague". Smallpox settles itself in small blood vessels of the skin and in the mouth and throat. The symptoms of smallpox are rash on the skin and blisters filled with raised liquid. [citation needed]
In the European Union it is indicated for the treatment of smallpox, mpox, and cowpox. [5] Tecovirimat can be taken by mouth and should be taken with a fatty meal. [14] While tpoxx did not show efficacy against mpox in monotherapy in clincal setting, in vitro assays showed strong inhibition of both vaccinia and mpox in combination therapies. [15]
Both Jynneos and ACAM2000 contain vaccinia virus that is closely related to, but less harmful than the viruses that cause smallpox and mpox. ACAM2000 uses a live, infectious form of the vaccinia ...
This committee was an action taken towards eradicating smallpox in Mexico through campaigning through systematic and routine work regarding the vaccine. They mainly pursued smaller and rural communities that had been harder or had less resources to combat the disease. [23] Smallpox was officially declared eradicated from Mexico in 1951.
The FBI and the Center for Disease Control and Prevention are investigating “questionable vials” labeled "smallpox" and found in a freezer last night at a Merck facility outside Philadelphia.