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Tamoxifen was initially made in 1962, by chemist Dora Richardson. [17] [18] It is on the World Health Organization's List of Essential Medicines. [19] Tamoxifen is available as a generic medication. [14] In 2020, it was the 317th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions. [20] [21]
Sivifene (A-007) was initially thought to be a SERM due to its structural similarity to tamoxifen but it was subsequently found not to bind to the estrogen receptor (ER). [8] Tesmilifene (DPPE; YMB-1002, BMS-217380-01) is also structurally related to tamoxifen but similarly does not bind to the ER and is not a SERM. [9] [10]
Local bookstores in the Seattle area described wariness over the physical presence of Amazon.com, with the University Book Store in the U District noting "different spending patterns" two months after the opening of Amazon's store; an Amazon spokesperson dismissed the notion that Amazon Books would interfere with independent bookstores and their operations, stating that "offline retail is a ...
List of books by Barbara Cartland; List of books by G. K. Chesterton; List of books by Agatha Christie; List of books by Jacques Derrida; List of works by Neil Gaiman; List of books by William Gibson; List of books by Graham Greene; List of books by Clive Hamilton; List of books by Friedrich Hayek; List of works by Søren Kierkegaard; List of ...
Open Library is an online project intended to create "one web page for every book ever published". Created by Aaron Swartz, [3] [4] Brewster Kahle, [5] Alexis Rossi, [6] Anand Chitipothu, [6] and Rebecca Hargrave Malamud, [6] Open Library is a project of the Internet Archive, a nonprofit organization.
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N-Desmethyltamoxifen (developmental code name ICI-55,548) is a major metabolite of tamoxifen, a selective estrogen receptor modulator (SERM). [1] [2] N-Desmethyltamoxifen is further metabolized into endoxifen (4-hydroxy-N-desmethyltamoxifen), which is thought to be the major active form of tamoxifen in the body.
Endoxifen is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromatase inhibitors, and fulvestrant). [3] [4] [5] The prodrug tamoxifen is metabolized by the CYP2D6 enzyme to produce endoxifen and afimoxifene (4-hydroxytamoxifen). [6]
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