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The Reproducibility Project is a series of crowdsourced collaborations aiming to reproduce published scientific studies, finding high rates of results which could not be replicated. It has resulted in two major initiatives focusing on the fields of psychology [ 1 ] and cancer biology. [ 2 ]
The Cancer Genome Atlas (TCGA) is a project to catalogue the genomic alterations responsible for cancer using genome sequencing and bioinformatics. [1] [2] The overarching goal was to apply high-throughput genome analysis techniques to improve the ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of the disease.
The goals of the project are to help sequence and catalog different cancer genomes. Beyond just sequencing the project's internal partners each have different areas of focus that will assist in the project's overall goal of determining unique ways for early detection of cancer, better prevention, and improved treatment for patients. [1]
The Cancer Genome Anatomy Project (CGAP), created by the National Cancer Institute (NCI) in 1997 and introduced by Al Gore, is an online database on normal, pre-cancerous and cancerous genomes. It also provides tools for viewing and analysis of the data, allowing for identification of genes involved in various aspects of tumor progression.
Tisagenlecleucel is an adoptive cell transfer therapy for B-cell acute lymphoblastic leukemia; T cells from a person with cancer are removed, genetically engineered to make a specific T-cell receptor (a chimeric T cell receptor, or "CAR-T") that reacts to the cancer, and are administered back to the person.
Welcome to WikiProject Biology, a WikiProject for discussing biology-related articles, editing issues, projects, and guidelines.The purpose of this project is to provide common ground for editors working in all biology-related projects, for seeking advice or requesting help from a broader community of biology editors, and for coordinating the categorization of biology articles.
Tumor cells express PD-L1 in high amounts which prevents T cells from attacking them. Another mechanism that cancer cells use is the downregulation of MHC I. Major histocompatibility complex class I (MHC I) molecules are expressed on cell surfaces with the role of alerting the immune system to the presence of infected cells.
This is a list of population genetics projects. Multiple populations. 1000 Genomes Project; ... This page was last edited on 5 August 2024, at 12:01 (UTC).