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The nuclear lamina consists of two components, lamins and nuclear lamin-associated membrane proteins. The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B 1, B 2) according to homology of their DNA sequences, biochemical properties and cellular localization during the cell cycle.
The nuclear envelope is made up of two lipid bilayer membranes, an inner nuclear membrane and an outer nuclear membrane. These membranes are connected to each other by nuclear pores. Two sets of intermediate filaments provide support for the nuclear envelope. An internal network forms the nuclear lamina on the inner nuclear membrane. [7]
Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. Lamins have elastic and mechanosensitive properties, and can alter gene regulation in a feedback response to mechanical cues. [1] Lamins are present in all animals but are not found in microorganisms, plants or fungi.
The nuclear pore complex (NPC) is a crucial cellular structure with a diameter of approximately 120 nanometers in vertebrates. Its channel varies from 5.2 nanometers in humans [14] to 10.7 nm in the frog Xenopus laevis, with a depth of roughly 45 nm. [15] Additionally, mRNA, being single-stranded, has a thickness ranging from 0.5 to 1 nm.
[1] [5] Animal intermediate filaments are subcategorized into six types based on similarities in amino acid sequence and protein structure. [6] Most types are cytoplasmic, but one type, Type V is a nuclear lamin. Unlike microtubules, IF distribution in cells shows no good correlation with the distribution of either mitochondria or endoplasmic ...
Laminin-1 EHS laminin α1β1γ1 Laminin-111: Laminin-2 Merosin α2β1γ1 Laminin-211 Laminin-3 S-laminin α1β2γ1 Laminin-121 Laminin-4 S-merosin α2β2γ1 Laminin-221 Laminin-5 / Laminin-5A Kalinin, epiligrin, nicein, ladsin α3Aβ3γ2 Laminin-332 / Laminin-3A32 Laminin-5B α3Bβ3γ2 Laminin-3B32 Laminin-6 / Laminin-6A K-laminin α3Aβ1γ1
The nuclear lamina consist of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated.
4001 16906 Ensembl ENSG00000113368 ENSMUSG00000024590 UniProt P20700 P14733 RefSeq (mRNA) NM_001198557 NM_005573 NM_010721 RefSeq (protein) NP_001185486 NP_005564 NP_034851 Location (UCSC) Chr 5: 126.78 – 126.84 Mb Chr 18: 56.84 – 56.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of ...