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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [ 8 ] [ 9 ] It may also be used for hiccups and muscle spasms near the end of life, [ 9 ] and off-label to treat alcohol use disorder [ 10 ] [ 11 ] or opioid withdrawal symptoms. [ 12 ]
Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication.
In 2008, Ameisen wrote a best-selling book, The End Of My Addiction, published in France as Le Dernier Verre (The Last Glass), describing his experience of curing his alcoholism with baclofen. [6] In 2007, an Italian team also showed the effectiveness and the safety of baclofen as a treatment for alcohol addiction. [7]
Baclofen in my view was probably just suppressing alcohol withdrawal symptoms. Baclofen's suppression of temporary withdrawal symptoms may be being misinterpreted as being a successful treatment of alcoholism. We need to be careful about adding primary sources, especially weak primary sources and giving undue weight.
Fentanyl sold as or laced into heroin has made the news in the past due to the numerous fatalities it causes when it appears on the market. Recently, Fentanyl and close analogues have been produced in pure powder form for very cheap. Dealers may cut with or sell heroin with Fentanyl due to the street cost of Fentanyl versus the cost of heroin.
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Friedländer's business philosophy opined that the pharmaceutical industry has a reliable basis in difficult economic times, since "A Jewish mother will always buy medicine for her children". In the Second World War , the company provided medicine to the allied forces and in particular to the British army present in the Middle East .
Intrathecal pumps require maintenance and need to be periodically refilled. How frequently this occurs is dependent on several factors, including drug concentration and dosage, and pump size. The refill frequency can range between one and six months for baclofen pumps. [2]