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12153 Ensembl ENSG00000168487 ENSMUSG00000022098 UniProt P13497 P98063 RefSeq (mRNA) NM_001199 NM_006128 NM_006129 NM_006130 NM_006131 NM_006132 NM_009755 NM_001360021 RefSeq (protein) NP_001190 NP_006120 NP_033885 NP_001346950 Location (UCSC) Chr 8: 22.17 – 22.21 Mb Chr 14: 70.47 – 70.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 1, also known as ...
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain. [ 3 ]
Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins. They belong to a class of receptor serine/threonine kinases that bind members of the TGF beta superfamily of ligands—the bone morphogenetic proteins. The three types of type I BMP receptors are ACVR1, BMPR1A and BMPR1B.
Bone morphogenetic protein receptor type-1B also known as CDw293 (cluster of differentiation w293) is a protein that in humans is encoded by the BMPR1B gene. [ 5 ] [ 6 ] Function
12166 Ensembl ENSG00000107779 ENSMUSG00000021796 UniProt P36894 P36895 RefSeq (mRNA) NM_004329 NM_009758 RefSeq (protein) NP_004320 NP_033888 Location (UCSC) Chr 10: 86.76 – 86.93 Mb Chr 14: 34.13 – 34.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene ...
This family of cytokines and hormones include activin, anti-Müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth , cell differentiation , homeostasis , osteogenesis , apoptosis and many other functions.
655 12162 Ensembl ENSG00000101144 ENSMUSG00000008999 UniProt P18075 P23359 RefSeq (mRNA) NM_001719 NM_007557 RefSeq (protein) NP_001710 NP_001710.1 NP_031583 Location (UCSC) Chr 20: 57.17 – 57.27 Mb Chr 2: 172.71 – 172.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is ...