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The antidotes for ethylene glycol poisoning are ethanol and fomepizole. This antidotal treatment forms the mainstay of management of ethylene glycol poisoning. The toxicity of ethylene glycol comes from its metabolism to glycolic acid and oxalic acid. The goal of pharmacotherapy is to prevent the formation of these metabolites.
Patricia Stallings (born 1964 or 1965) is an American woman who was wrongfully convicted of murder after the death of her son Ryan on September 7, 1989. Because testing seemed to indicate an elevated level of ethylene glycol in Ryan's blood, authorities suspected antifreeze poisoning and they arrested Stallings the next day.
Ethylene glycol may also be one of the minor ingredients in screen cleaning solutions, along with the main ingredient isopropyl alcohol. Ethylene glycol is commonly used as a preservative for biological specimens, especially in secondary schools during dissection as a safer alternative to formaldehyde. It is also used as part of the water-based ...
Fomepizole is used to treat ethylene glycol and methanol poisoning. It acts to inhibit the breakdown of these toxins into their active toxic metabolites. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase, [6] found in the liver. This enzyme plays a key role in the metabolism of ethylene glycol, and of methanol.
The snacks were contaminated with ethylene glycol, probably originating from contamined propylene glycol. All products made by Bassar were recalled on the 7th of September. [113] 2024 – Applesauce products containing cinnamon were found to contain lead chromate, leading to reports of child lead poisoning across the United States. The source ...
Previously, most of Brent's research focused on the use of fomepizole as a treatment for both methanol and ethylene glycol poisoning, and he led a trial of this drug which resulted in the FDA approving it in December 1997. [5]
At 9:42 a.m. on the morning of Julie’s death, someone searched the internet on the family’s desktop computer for diminished consciousness from ethylene glycol poisoning, Jambois said. The two ...
The cough syrup in question was produced by Maiden Pharmaceuticals, and it has been implicated in child deaths in Gambia. Tests conducted by two independent laboratories on behalf of the WHO confirmed the presence of lethal toxins—ethylene glycol and diethylene glycol in the syrup. Indian authorities, however, did not find any toxins, but did ...