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  2. CYP3A4 - Wikipedia

    en.wikipedia.org/wiki/CYP3A4

    a Moderate inhibitor causes at least a 2-fold increase in the plasma AUC values, or 50–80% decrease in clearance. [39] a Weak inhibitor causes at least a 1.25-fold but less than 2-fold increase in the plasma AUC values, or 20–50% decrease in clearance. [39] The inhibitors of CYP3A4 are the following substances.

  3. Angiotensin-converting enzyme - Wikipedia

    en.wikipedia.org/wiki/Angiotensin-converting_enzyme

    Reflecting the critical role of zinc, ACE can be inhibited by metal-chelating agents. [14] ACE in complex with inhibitor lisinopril, zinc cation shown in grey, chloride anions in yellow. Based on PyMOL rendering of PDB 1o86. The picture shows that lisinopril is a competitive inhibitor, since it and angiotensin I are similar structurally.

  4. Pomegranate juice - Wikipedia

    en.wikipedia.org/wiki/Pomegranate_juice

    Pomegranate molasses is a fruit syrup made from pomegranate juice, not sugarcane-derived molasses. It is a reduction from the juice of a tart variety of pomegranate, evaporated to form a thick, dark red liquid. Pomegranate molasses is often used on top of meatloaf or meatballs to give them a shiny glaze and can be also be used for drizzling ...

  5. Grapefruit–drug interactions - Wikipedia

    en.wikipedia.org/wiki/Grapefruit–drug_interactions

    The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. [ 9 ] [ 10 ] A 2005 medical review advised patients to avoid all citrus juices until further research clarifies the risks. [ 11 ]

  6. Renin–angiotensin system - Wikipedia

    en.wikipedia.org/wiki/Renin–angiotensin_system

    ACE inhibitors of angiotensin-converting enzyme inhibitors are often used to reduce the formation of the more potent angiotensin II. Captopril is an example of an ACE inhibitor. ACE cleaves a number of other peptides, and in this capacity is an important regulator of the kinin–kallikrein system, as such blocking ACE can lead to side effects. [18]

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  8. Cardiovascular agents - Wikipedia

    en.wikipedia.org/wiki/Cardiovascular_agents

    Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]

  9. Lions have been hit hardest by rash of injuries, though NFL ...

    www.aol.com/lions-hit-hardest-rash-injuries...

    Special teams ace Khalil Dorsey had season-ending surgery after breaking his leg in the same game. Cornerback Carlton Davis is out indefinitely with a jaw injury. The Lions already had a league ...