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Proctosigmoiditis and left-sided colitis involves the lower colon, from the rectum up the left side of the patient. Patients often respond to topical agents alone, such as Mesalazine, or hydrocortisone enemas. Again, the Mesalazine is preferred for maintenance therapy. Initially a 4 g Mesalazine enema (Rowasa) is given nightly.
Diet can play a role in symptoms of patients with ulcerative colitis. [161] The most avoided foods by patients are spicy foods, dairy products, alcohol, fruits and vegetables and carbonated beverages; these foods are mainly avoided during remission and to prevent relapse.
A low-fiber diet is not a no-fiber diet. A 2015 review article recommends less than 10 grams of fiber per day. [12] Other sources recommend that a patient on a low-fiber diet eat no more than 10–15 grams of fiber per day. [5] Some sources recommend serving sizes that contain no more than 2 grams per serving. [5] [6]
People with ulcerative colitis typically initially suffer from bloody diarrhea, says Dr. Ece A. Mutlu, a professor of medicine and an IBD specialist at Rush University Medical Center in Chicago.
An anti-TL1A monoclonal antibody called tulisokibart may help people with moderate to severe ulcerative colitis achieve clinical remission, a phase 2 trial has found.
Mirikizumab, a drug currently approved by the Food and Drug Administration (FDA) for the treatment of ulcerative colitis, also sends Crohn's disease into clinical remission, new findings suggest.
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