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The cell cycle in eukaryotes: I = Interphase, M = Mitosis, G 0 = Gap 0, G 1 = Gap 1, G 2 = Gap 2, S = Synthesis, G 3 = Gap 3. Cell division is the process by which a parent cell divides into two daughter cells. [1] Cell division usually occurs as part of a larger cell cycle in which the cell grows and replicates its chromosome(s) before dividing.
Cytokinesis illustration Ciliate undergoing cytokinesis, with the cleavage furrow being clearly visible. Cytokinesis (/ ˌ s aɪ t oʊ k ɪ ˈ n iː s ɪ s /) is the part of the cell division process and part of mitosis during which the cytoplasm of a single eukaryotic cell divides into two daughter cells.
In molecular biology, an actomyosin ring or contractile ring, is a prominent structure during cytokinesis. [1] It forms perpendicular to the axis of the spindle apparatus [ 2 ] towards the end of telophase , in which sister chromatids are identically separated at the opposite sides of the spindle forming nuclei (Figure 1).
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
During mitosis, the chromosomes, which have already duplicated during interphase, condense and attach to spindle fibers that pull one copy of each chromosome to opposite sides of the cell. [4] The result is two genetically identical daughter nuclei. The rest of the cell may then continue to divide by cytokinesis to produce two daughter cells. [5]
Fig. 2 Irreversible and bistable switch in mitotic exit with control parameter being Sic1 level and order parameter being cell cycle phases. Because eukaryotic cell cycle involves a variety of proteins and regulatory interactions, dynamical systems approach can be taken to simplify a complex biological circuit into a general framework for ...
During cytokinesis in animal cells, a contractile ring made up of actin filaments forms, and this ring pinches to divide the cell into two daughter cells. [6] The cells are able to separate due to the formation of a cleavage furrow, which pinches in a centripetal fashion (from the outside of the cell towards the center of the cell). [6]
Budding yeast form a bud from the mother cell. This bud grows during the cell cycle and detaches; fission yeast divide by forming a cell wall [30] Cytokinesis begins at G1 for budding yeast, while cytokinesis begins at G2 for fission yeast. Fission yeast "select" the midpoint, whereas budding yeast "select" a bud site [38]