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Serious haematological disorders and porphyria (due to the sulfonamide component of the preparation). Severe chronic kidney disease (CrCl <15 ml/min) where repeated measurements of the plasma concentration cannot be performed
Absorption. Sulfamethoxazole is well-absorbed when administered topically. It is rapidly absorbed when it is orally administered. [1] Distribution. Sulfamethoxazole distributes into most body tissues as well as into sputum, vaginal fluid, and middle ear fluid. [8] [11] It also crosses the placenta. About 70% of the drug is bound to plasma proteins.
In other cases, topical is defined as applied to a localized area of the body or to the surface of a body part regardless of the location of the effect. [4] [5] By this definition, topical administration also includes transdermal application, where the substance is administered onto the skin but is absorbed into the body to attain systemic ...
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
Parts-per-million cube of relative abundance by mass of elements in an average adult human body down to 1 ppm. About 99% of the mass of the human body is made up of six elements: oxygen, carbon, hydrogen, nitrogen, calcium, and phosphorus. Only about 0.85% is composed of another five elements: potassium, sulfur, sodium, chlorine, and magnesium ...
No human trials scheduled: Binds fatty acid precursors to cell wall Malacidins: Uncultured Bacterium: Gram-positive, including antibiotic resistant S. aureus: No human trials scheduled: Binds fatty acid precursors to cell wall Halicin: Anti-diabetic drug Clostridiodes difficile, Acinetobacter baumannii, and Mycobacterium tuberculosis: No human ...
Gastrointestinal disorders or interpatient variability in oral contraceptive absorption affecting ethinylestradiol serum levels in the blood. [55] Women with menstrual irregularities may be at higher risk of failure and should be advised to use backup contraception during antibiotic treatment and for one week after its completion. If patient ...
Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) due to the unknown etiology of some of them, are a heterogenous group of demyelinating diseases - conditions that cause damage to myelin, the protective sheath of nerve fibers - that occur against the background of an acute or chronic inflammatory process.