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Whole-brain irradiation is used as a primary treatment method in patients with multiple lesions and is also used alongside surgical resection when patients have single and accessible tumors. [6] However, it often causes severe side effects, including radiation necrosis , dementia , toxic leukoencephalopathy , partial to complete hair loss ...
At this dose, approximately 6391 people would have to be exposed to cause 1 case of brain cancer. [8] Ionizing radiation to the head as part of treatment for other cancers is also a risk factor for developing brain cancer. [24] Mutations and deletions of tumor suppressor genes, such as P53, are thought to be the cause of some forms of brain ...
"Adult Central Nervous System Tumors Treatment (PDQ®): Patient Version". National Cancer Institute (US). PMID 26389458. "Adult Central Nervous System Tumors Treatment (PDQ®)–Patient Version". National Cancer Institute. 15 November 2019. Brain and other central nervous system tumors | Cancer Australia Children's Cancers. (2019).
Supportive treatment focuses on relieving symptoms and improving the patient's neurologic function. The primary supportive agents are anticonvulsants and corticosteroids. Historically, around 90% of patients with glioblastoma underwent anticonvulsant treatment, although only an estimated 40% of patients required this treatment.
Which one patients get can depend on where they get treatment. After three years, 57% of those who got chemo and surgery were alive, compared to 51% of those who got chemo, surgery and radiation.
Extended survival has been seen, however, in a subgroup of AIDS patients with CD4 counts of more than 200 and no concurrent opportunistic infections, who can tolerate aggressive therapy consisting of either methotrexate monotherapy or vincristine, procarbazine, or whole brain radiotherapy. These patients have a median survival of 10–18 months.
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