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Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
Dantrolene has been used when needed to reduce muscle rigidity, and dopamine pathway medications such as bromocriptine have shown benefit. [44] Dantrolene may act centrally on thermoregulatory pathways to lower the temperature. [7] Dantrolene also inhibits calcium release from the muscle sarcoplasmic reticulum to cause muscle relaxation. [7]
Antipsychotic medications may cause neuroleptic malignant syndrome, which can cause severe muscle rigidity with rhabdomyolysis and hyperpyrexia; Neuromuscular blocking agents used in anesthesia may result in malignant hyperthermia, also associated with rhabdomyolysis; Medications that cause serotonin syndrome, such as SSRIs
Loss of muscle coordination or twitching muscles. Muscle rigidity. Tremor. Heavy sweating. Diarrhea. Headache. Shivering. Goosebumps. Severe serotonin syndrome can be life-threatening. Signs ...
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible. [1] Symptoms include muscle rigidity, fever, and a fast heart rate. [1] Complications can include muscle breakdown and high blood potassium.
Antipsychotic drug treatment is a key component of ... Muscle rigidity; ... If data on the propensity of a particular drug to cause a particular AE is unavailable an ...
Late-onset dyskinesia, also known as tardive dyskinesia, occurs after long-term treatment with an antipsychotic drug such as haloperidol (Haldol) or amoxapine (Asendin). The symptoms include tremors and writhing movements of the body and limbs, and abnormal movements in the face, mouth, and tongue – including involuntary lip smacking, repetitive pouting of the lips, and tongue protrusions.
Chest wall. Wooden chest syndrome is a rigidity of the chest following the administration of high doses of opioids during anesthesia [1]. [1]Wooden chest syndrome describes marked muscle rigidity — especially involving the thoracic and abdominal muscles — that is an occasional adverse effect associated with the intravenous administration of lipophilic synthetic opioids such as fentanyl [2].