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Photo 51 became a crucial data source [17] that led to the development of the DNA model and confirmed the prior postulated double helical structure of DNA, which were presented in the series of three articles in the journal Nature in 1953. Cartoon explanation of how Photo 51 captured the double helix structure of DNA.
The Path to The Double Helix: Discovery of DNA. MacMillan. ISBN 978-0-486-68117-7. (with foreword by Francis Crick; revised in 1994, with a 9-page postscript.) Watson, James D. (1980). The Double Helix: A Personal Account of the Discovery of the Structure of DNA. Atheneum. ISBN 978-0-689-70602-8. (first published in 1968) Wilkins, Maurice (2003).
The double-helix model of DNA structure was first published in the journal Nature by James Watson and Francis Crick in 1953, [6] (X,Y,Z coordinates in 1954 [7]) based on the work of Rosalind Franklin and her student Raymond Gosling, who took the crucial X-ray diffraction image of DNA labeled as "Photo 51", [8] [9] and Maurice Wilkins, Alexander Stokes, and Herbert Wilson, [10] and base-pairing ...
The separation of the two linked daughter DNA strands during replication either required DNA to have a net-zero helical twist, or for the strands to be cut, crossed, and rejoined. It was this apparent contradictions that early non-helical models attempted to address until the discovery of topoisomerases in 1970 resolved the problem. [16] [17]
Watson and Crick completed their model, which is now accepted as the first correct model of the double helix of DNA. On 28 February 1953 Crick interrupted patrons' lunchtime at The Eagle pub in Cambridge, England to announce that he and Watson had "discovered the secret of life". [209] Pencil sketch of the DNA double helix by Francis Crick in 1953
In 1953, James Watson and Francis Crick discovered the double helical structure of the DNA molecule based on the discoveries made by Rosalind Franklin. [5] In 1961, François Jacob and Jacques Monod demonstrated that the products of certain genes regulated the expression of other genes by acting upon specific sites at the edge of those genes.
February 15 – Linus Pauling proposes a DNA triple helix structure, [1] which is rapidly shown to be incorrect. 25 April 1953: the DNA double helix is first formally described. February 28 – Francis Crick and James Watson enter The Eagle, Cambridge, for a pub lunch announcing "We have discovered the secret of life." [2]
On April 25, 1953 James D. Watson and Francis Crick published "a radically different structure" for DNA, [3] thereby founding the field of molecular genetics. Their structural model featured two strands of complementary base-paired DNA, running in opposite directions as a double helix. They concluded their report saying that "It has not escaped ...