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The chief and parietal cells produce and secrete mucus (F) to protect the lining of the stomach (C) against the harsh pH of stomach acid. The mucus is basic, while the stomach acid (A) is acidic. In the human digestive system, mucus is used as a lubricant for materials that must pass over membranes, e.g., food passing down the esophagus.
Pepsin is a protease that can digest and damage stomach cells. To prevent these disastrous effects, mucus and bicarbonate ions (HCO 3 −) are secreted by the foveolar cells. The mucus allows the acid at pH above 4 to penetrate lining, but below pH 4 (i.e. when acid is more concentrated) the acid cannot penetrate the mucus.
The mucosa is composed of one or more layers of epithelial cells that secrete mucus, and an underlying lamina propria of loose connective tissue. [1] The type of cells and type of mucus secreted vary from organ to organ and each can differ along a given tract. [2] [3]
Mucous neck cells produce mucus, parietal cells secrete hydrochloric acid and intrinsic factor, chief cells secrete pepsinogen and gastric lipase. [4] The other type of gastric gland is the pyloric gland which is an endocrine gland that secretes the hormone gastrin produced by its G cells.
A special mucus covering, derived from mucus secreted by surface epithelial cells and Foveolar cells. This insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa. The mucus protects the gastric mucosa from autodigestion by e.g. pepsin and from erosion by acids and other caustic materials that are ingested.
The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
These are known as non-ciliated columnar epithelium. Non-ciliated simple columnar epithelium is made up of glandular goblet cells which secrete mucin to form mucus. [1] The rest of the cell is made up of cytoplasm with membrane bound secretory granules which secrete the mucin, and are found towards the apical surface of the cell. [1]
Mucus is released in the stomach and intestine, and serves to lubricate and protect the inner mucosa of the tract. It is composed of a specific family of glycoproteins termed mucins and is generally very viscous. Mucus is made by two types of specialized cells termed mucous cells in the stomach and goblet cells in the intestines. Signals for ...
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