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Fuzzy clustering (also referred to as soft clustering or soft k-means) is a form of clustering in which each data point can belong to more than one cluster.. Clustering or cluster analysis involves assigning data points to clusters such that items in the same cluster are as similar as possible, while items belonging to different clusters are as dissimilar as possible.
Hard clustering: each object belongs to a cluster or not; Soft clustering (also: fuzzy clustering): each object belongs to each cluster to a certain degree (for example, a likelihood of belonging to the cluster) There are also finer distinctions possible, for example: Strict partitioning clustering: each object belongs to exactly one cluster
Systems biology involves the use of computer simulations of cellular subsystems (such as the networks of metabolites and enzymes that comprise metabolism, signal transduction pathways and gene regulatory networks) to both analyze and visualize the complex connections of these cellular processes.
Sometimes one or more clusters deviate strongly from the Gaussian assumption. If a Gaussian mixture is fitted to such data, a strongly non-Gaussian cluster will often be represented by several mixture components rather than a single one. In that case, cluster merging can be used to find a better clustering. [20]
For a clustering example, suppose that five taxa (to ) have been clustered by UPGMA based on a matrix of genetic distances.The hierarchical clustering dendrogram would show a column of five nodes representing the initial data (here individual taxa), and the remaining nodes represent the clusters to which the data belong, with the arrows representing the distance (dissimilarity).
WGCNA can be used as a data reduction technique (related to oblique factor analysis), as a clustering method (fuzzy clustering), as a feature selection method (e.g. as gene screening method), as a framework for integrating complementary (genomic) data (based on weighted correlations between quantitative variables), and as a data exploratory ...
The information bottleneck method is a technique in information theory introduced by Naftali Tishby, Fernando C. Pereira, and William Bialek. [1] It is designed for finding the best tradeoff between accuracy and complexity (compression) when summarizing (e.g. clustering) a random variable X, given a joint probability distribution p(X,Y) between X and an observed relevant variable Y - and self ...
Sequence clustering is often used to make a non-redundant set of representative sequences. Sequence clusters are often synonymous with (but not identical to) protein families . Determining a representative tertiary structure for each sequence cluster is the aim of many structural genomics initiatives.