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Tazarotene, sold under the brand name Tazorac, among others, is a third-generation prescription topical retinoid. [2] [3] It is primarily used for the treatment of plaque psoriasis and acne. [4] Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. [4] It is a member of the acetylenic class of retinoids. [4]
It combines 0.01% halobetasol propionate (a corticosteroid that reduces inflammation and suppresses the immune system) and 0.045% tazarotene (a retinoid that promotes normal skin cell turnover and has anti-inflammatory effects) in a lotion formulation.
Tazarotene (Tazorac®): Prevents skin cells from building up and reduces inflammation, though it can be irritating Using a moisturizer alongside a retinoid is usually recommended to avoid over ...
Ulobetasol propionate is usually supplied as a 0.05% topical cream. [1] Ulobetasol is the strongest topical steroid available. [citation needed] It is also sold with tazarotene with 0.01% halobetasol and 0.045% tazarotene as a lotion branded as Duobrii (Bausch Health). It is available as a generic medication. [5]
Reviewers' main criticism applies not to the cream itself, but the container: "Love the cream, but the straw to the pump is way too short. Leaves about 1/3 of the product," one user said.
Third generation retinoids have narrow biological roles due to their constrained structure, with adapalene mimicking the effects of isotretinoin, [10] bexarotene binding only the Retinoid X receptors, and tazarotene binding the Retinoic acid receptor beta and Retinoic acid receptor gamma forms. [11]
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