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The perisinusoidal space also contains hepatic stellate cells (also known as Ito cells or lipocytes), which store vitamin A in characteristic lipid droplets. [ 2 ] This space may be obliterated in liver disease , leading to decreased uptake by hepatocytes of nutrients and wastes such as bilirubin .
The liver plays the major role in producing proteins that are secreted into the blood, including major plasma proteins, factors in hemostasis and fibrinolysis, carrier proteins, hormones, prohormones and apolipoprotein:
The ductus venosus carries blood from the left portal vein to the left hepatic vein and then to the inferior vena cava, allowing placental blood to bypass the liver. In the fetus, the liver does not perform the normal digestive processes and filtration of the infant liver because nutrients are received directly from the mother via the placenta.
In normal liver, stellate cells are described as being in a quiescent state. Quiescent stellate cells represent 5-8% of the total number of liver cells. [4] Each cell has several long cytoplasmic protrusions that extend from the cell body and wrap around the sinusoids. [5] The lipid droplets in the cell body store vitamin A as retinyl palmitate ...
A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.
The bare area of the liver is found on the posterosuperior surface of the right lobe of the liver. [1] This lies close to the thoracic diaphragm. It is the only part of the liver that has no peritoneal covering. [1] [2] It lies between the two layers of the coronary ligament, as well as the right triangular ligament. [1]
The liver is the biggest gland of the body. It has a wide variety of functions that range from the destruction of old blood cells to the control of the whole metabolism of macromolecules. [3] In the fetus, the liver works as a principal center for hematopoiesis, function that is later replaced by the bone marrow. This hematopoietic function is ...
In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue , consisting of portal triads, hepatocytes arranged in linear cords between a capillary network, and a central vein .