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This type of amyloidosis often has a better prognosis than the varieties that affect multiple organ systems. Typical sites for localized amyloidosis include the bladder, skin, throat or lungs. Correct diagnosis is important so that treatments that affect the entire body can be avoided.
AL amyloidosis (amyloid light chain or primary amyloidosis) is a rare disease that happens when abnormal light chain proteins in your body gather on your organs and tissues. It's a serious illness that may become chronic or may cause life-threatening medical conditions.
Overall, people with AA amyloidosis who undergo proper treatment can have a good outlook. The average life expectancy after diagnosis is 11 years. The earlier a person is diagnosed, the better their outlook tends to be. Treatments that begin early enough can often reverse the formation of AA amyloid deposits and help prevent kidney damage.
As disease outcomes improve, AL amyloidosis-unrelated factors may impact mortality. In this study, we evaluated survival trends and primary causes of death among 2337 individuals with AL...
The treatment and prognosis of AL amyloidosis will be reviewed in detail here. The pathogenesis, clinical features, and diagnosis of these disorders and the diagnosis and management of amyloid cardiomyopathy and renal amyloid are discussed in detail separately.
There's no cure for amyloidosis. But treatment can help manage signs and symptoms and limit further production of amyloid protein. If the amyloidosis has been triggered by another condition, such as rheumatoid arthritis or tuberculosis, treating the underlying condition can be helpful. Chemotherapy.
Healthcare providers typically diagnose amyloidosis in people ages 50 to 65. The diseases affect more men and people assigned male at birth than women and people assigned female at birth. What are the three common types of amyloidosis?
More people with AL (primary) amyloidosis are living longer lives, with 1 in 5 patients living for 10 years after diagnosis. Hereditary amyloidosis is generally considered less serious than...
Amyloidosis is a buildup of abnormal proteins called amyloid, and can affect the heart, brain and other parts of the body. Amyloidosis is more common in older adults, and in men.
The presence or absence of cardiac involvement with amyloid is the most important prognostic factor. Treatment can range from observation to oral chemotherapy to hematopoietic stem cell transplantation. A practical understanding of the mechanisms underlying this disease can lead to prompt diagnosis and early therapeutic intervention.