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Melatonin is generally safe for short-term use. Unlike with many sleep medications, with melatonin you are unlikely to become dependent on it, have less response to it after repeated use or experience a hangover effect. The most common melatonin side effects include: Headache; Dizziness; Nausea; Daytime drowsiness
For most adults, melatonin has minimal and mild side effects. However, older people need to be careful with melatonin because it presents different risks in this population. One study found that older people who are more prone to falls may be at a higher risk of fractures when taking melatonin.
Melatonin can cause: Less common melatonin side effects might include short-lasting feelings of depression, mild tremor, mild anxiety, abdominal cramps, irritability, reduced alertness, confusion or disorientation. Because melatonin can cause daytime drowsiness, don't drive or use machinery within five hours of taking the supplement.
Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal pathways of transmission to the pineal gland.
Melatonin supplements are generally considered safe in the short term, even when taken in very high doses. However, more research on its long-term safety is needed, especially in children (11). A...
Serious side effects include worsening of seizures; changes in heart rate and blood pressure; decrease in glucose tolerance; and possible drug interactions for people taking seizure disorder medications, antidepressants or blood thinners. "Because something is marketed as 'natural' or a product is sold over the counter doesn't mean it's harmless."
Darkness triggers the body to make more melatonin, which signals the body to sleep. Light decreases melatonin production and signals the body to be awake. Some people who have trouble sleeping...