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Organophosphate-induced delayed neuropathy (OPIDN), also called organophosphate-induced delayed polyneuropathy (OPIDP), is a neuropathy caused by killing of neurons in the central nervous system, especially in the spinal cord, as a result of acute or chronic organophosphate poisoning.
Symptoms of the central nervous system are possible, but are less frequent and severe than those associated with organophosphate poisoning. Possible symptoms include: [1] [3] Headache; Anxiety; Agitation; Ataxia; Seizures, which may progress to a coma; Apnea caused by disruption of the respiratory center of the brain
Organophosphorus acid anhydrolase (OPAA) is an enzyme that been shown to be particularly effective in detoxifying organophosphorus-containing compounds, such as deadly nerve gas used in chemical warfare. [1]
In March 2018, Sergei Skripal and his daughter were poisoned in Salisbury, England, with an organophosphate poison known as a Novichok agent. [59] Both fell unconscious while sitting on a park bench. A first responder to the scene also became contaminated and had symptoms of organophosphate poisoning. All three survived after hospital treatment.
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. [1] It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant – alters the normal activity of the nervous system in such a ...
CityPlex Towers is a complex of three high-rise office towers located at 81st Street and Lewis Avenue in Tulsa, Oklahoma. The complex was originally constructed by Oral Roberts University as City of Faith Medical and Research Center and meant to be a major charismatic Christian hospital. The complex is now home to 3 individual hospitals with ...
The Oklahoma Health Center is a 325-acre medical district in Oklahoma City, Oklahoma, located one mile northeast of downtown Oklahoma City and just south of the Oklahoma State Capitol, near the confluence of Interstates 35, 40, and 235. Over 30 organizations are members of the Oklahoma Health Center Foundation. [1]
Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. [1] It is used to treat organophosphate poisoning [2] in conjunction with atropine and either diazepam or midazolam. It is a white solid.