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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
Due to reported severe adverse effects of ticlopidine second and third-thienopyridines, clopidogrel and prasugrel, were developed. [ 5 ] When ticlopidine and clopidogrel were first brought to the market, ticlodipine in 1978 and clopidogrel in 1998, the mechanism of action of these two major antithrombotic drugs was not fully understood.
[18] [19] Unlike clopidogrel, prasugrel is effective in most individual with the exception in patients over the age of 75, weight under 60 kg, and patients with a history of stroke or TIA due to increased risk of bleeding, [20] [4] although several cases have been reported of decreased responsiveness to prasugrel. [21]
Both aspirin and clopidogrel may be useful in the first few weeks after a minor stroke or high-risk TIA. [128] Clopidogrel has less side effects than ticlopidine. [127] Dipyridamole can be added to aspirin therapy to provide a small additional benefit, even though headache is a common side effect. [129]
Regular screenings for high blood pressure can help determine whether you’re at risk of health issues such as heart disease and stroke. A stroke, for example, can cause serious brain damage.
Consistently with its reversible mode of action, ticagrelor is known to act faster and shorter than clopidogrel. [35] This means it has to be taken twice instead of once a day which is a disadvantage in respect of compliance, but its effects are more quickly reversible which can be useful before surgery or if side effects occur. [24] [36]
Alan says that Ozempic can “potentially” cause personality changes. “Personality changes, as defined by alterations in behavior, mood, or cognition, are not commonly reported side effects of ...
According to the New York Times, here's exactly how to play Strands: Find theme words to fill the board. Theme words stay highlighted in blue when found.