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Following is a table of selected substrates, inducers and inhibitors of CYP1A2. Inhibitors of CYP1A2 can be classified by their potency, such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or more than 80% decrease in clearance thereof. [18]
"Indiana University Department of Medicine Clinical Pharmacology Drug Interactions Flockhart Table ™". "INHIBITORS, INDUCERS AND SUBSTRATES OF CYTOCHROME P450 ISOZYMES". "The Life Raft Group: Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6". "DRUGBANK Online: Cytochrome P-450 Enzyme Inhibitors".
Pages in category "CYP1A2 inhibitors" The following 15 pages are in this category, out of 15 total. This list may not reflect recent changes. A. Aciclovir ...
Cytochrome P450 inhibitors is a category of agents that inhibit Cytochrome ... CYP1A2 inhibitors (15 P) CYP2C8 inhibitors ... This list may not reflect recent changes. A.
Clozapine, imipramine, paracetamol, phenacetin Heterocyclic aryl amines Inducible and CYP1A2 5-10% deficient oxidize uroporphyrinogen to uroporphyrin (CYP1A2) in heme metabolism, but they may have additional undiscovered endogenous substrates. are inducible by some polycyclic hydrocarbons, some of which are found in cigarette smoke and charred ...
Comparatively, the parent drug is a poor inhibitor of COX-2 byproducts, particularly prostaglandins. It may be less nephrotoxic than indomethacin. [7] There are two known polymorphs of the compound. [8] Nabumetone has little effect on renal prostaglandin secretion and less of an association with heart failure than other traditional drugs of the ...
This is a list of chemotherapeutic agents, also known as cytotoxic agents or cytostatic drugs, that are known to be of use in chemotherapy for cancer.This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision.
It is an inhibitor of CYP1A2. [1] References This page was last edited on 30 January 2023, at 12:33 (UTC). Text is available under the Creative ...
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